ICIN - Netherlands Heart Institute
 

Onderzoek

Projecten
Durrer Center
Stimuleringsfonds

Onderzoeksprojecten

Hieronder treft u een overzicht van al het lopende onderzoek van ICIN.

De projecten zijn onderverdeeld in vijf onderzoekslijnen:
- aangeboren hartafwijkingen;
- atherosclerose;
- ritemstoornissen;
- genetica en
- beeldtechniek.

Lopende projecten

02403: Gender study
GENetic DEterminants of Restenosis (GENDER): from candidate approach to GWAS.
januari 2003
Projectleider: Prof.dr. J.W. Jukema

03602: Concor registration
CONgenitale CORvitia, National registration of adult patients with congenital heart disease (CHD).
maart 2000 - december 2013
Projectleider: Mw. Prof.dr. B.J.M. Mulder

03604: Concor - Angiotensin II receptor blockers
The effect of angiontensin II receptor blockers in patients with a systemic right ventricle (RV).
mei 2006 - juli 2013
Projectleider: Mw. Prof.dr. B.J.M. Mulder

03606: Concor - High dose statins and intima-media thickness
Prospective multi-centre study to evaluate the effect of high dose statins on the intima-media thickness (IMT).
september 2007
Projectleider: Mw. Prof.dr. B.J.M. Mulder

03607: Concor - Healthcare
Predicting health care use and perceived health care needs in patients with congenital heart disease.
juni 2008 - december 2012
Projectleider: Mw. Prof.dr. B.J.M. Mulder

03608: Concor - Arrhythmias in adults with CHD
Study for the occurrence of arrhythmias and sudden cardiac death in congenital heart disease (CHD).
juni 2008 - december 2012
Projectleider: Mw. Prof.dr. B.J.M. Mulder

03611: Concor - Genes for heart repair and plasticity
Search for genes and mutations implied in cardiac development and human congenital heart disease (CHD).
juni 2008 - september 2013
Projectleider: Mw. Prof.dr. B.J.M. Mulder

03612: Concor - Compare study
Compare: COzaar in Marfan PAtients Reduces aortic Enlargement.
januari 2009 - januari 2013
Projectleider: Dr. M. Groenink

03613: Concor - Facing the future of adults with congenital heart disease
Study for the long-term prognosis of adult patients with congenital heart disease (CHD).
februari 2009 - februari 2013
Projectleider: Mw. Prof.dr. B.J.M. Mulder

03614: Concor - BOCA study
The effect of peri-operative bosentan on clinical outcome in patients with congneital heart disease.
juli 2010 - juli 2014
Projectleider: Mw. Prof.dr. B.J.M. Mulder

03615: Epidemiology and Early Detection of Pulmonary Arterial Hypertension in adults with congenital heart disease
Aim of this study is to assess the prevalence of pulmonary arterial hypertension in congenital heart disease. Moreover, drs. Annelieke van Riel will aim to provide further insight into pulmonary hemod
juni 2011 - juni 2015
Projectleider: Mw. Prof.dr. B.J.M. Mulder

03808: siRNA study cardiac arrhythmias
siRNA study on treatment for sudden cardiac death due to cardiac arrhythmias.
januari 2009 - december 2013
Projectleider: Prof.dr.ir. J.M.T. de Bakker

04304: MRI study
Assessment of myocardial viability with magnetic resonance imaging techniques.
december 2006 - september 2012
Projectleider: Prof.dr. P.A.F.M. Doevendans

04602: Zahara II study
Pregnancy in Congenital Heart Disease II (Zahara II)
mei 2008 - mei 2012
Projectleider: Mw. Dr. P.G. Pieper

04603: Prostava study
Functional outcome and quality of life in adult congenital heart disease patients with proethetic valves.
januari 2010 - januari 2013
Projectleider: Mw. Dr. P.G. Pieper

04804: Marcc studie
MAgnetic Resonance and CT in suspected Coronary artery disease.
februari 2007
Projectleider: Prof.dr. A.C. van Rossum

04805: Evaluation by magnetic resonance imaging.
Pathophysiological mechanisms of hypertrophy in hypertrophic cardiomyopathy.
mei 2008 - mei 2012
Projectleider: Prof.dr. A.C. van Rossum

04902: Sonolysis study
Therapeutic application of ultrasound.
september 2007
Projectleider: Dr. O. Kamp

04903: 3D-Echo study
Clinical Assessment of the Left Ventricle by Real-Time 3D Echocardiography.
oktober 2007
Projectleider: Dr. O. Kamp

04904: Directing adipose derived stem cells
Directing adipose derived stem cells to the area at risk in the heart after myocardial infarction using targeted microbubbles.
januari 2009 - januari 2013
Projectleider: Dr. O. Kamp

05102: 64-slice MSCT
64-slice CTA coronary angiography, SPECT and conventional angiography.
januari 2007
Projectleider: Prof. dr. J.J. Bax

05103: CAMPER study
Modification of risk with MSCT: CT coronary angiography in high-risk cardiac asymptomatic patients.
januari 2008 - januari 2013
Projectleider: Prof.dr. P.J. de Feyter

05104: Diacarm study
DIAbetes CAardiovascular Risk Management
juni 2009 - juni 2012
Projectleider: Prof. dr. J.J. Bax

05106: Fellowship
november 2009
Projectleider: Prof. dr. J.J. Bax

05107: Fellowship
juni 2010
Projectleider: Prof. dr. J.J. Bax

05202: Race III study
Routine versus aggressive upstream rhythm control for prevention of early atrial fibrillation in heart failure
januari 2009 - januari 2014
Projectleider: Mw. Prof.dr. I.C. van Gelder

05301: Stem cell derived cardiomyocytes for myocardial repair
Role of epicardium-derived cells (EPDCs) in cardiomyocyte differentiation
oktober 2004
Projectleider: Prof.dr. P.A.F.M. Doevendans

05305: Cardiac regeneration
Cell-based therapies for myocardial repair.
oktober 2004 - april 2013
Projectleider: Prof.dr. P.A.F.M. Doevendans

05501: Hebe 1 trial and follow up
Multicenter, randomized trial of intracoronary infusion of autologous mononuclear bone marrow cells or peripheral mononuclear blood cells after primary percutaneous coronary intervention (PCI).
april 2005 - november 2012
Projectleider: Prof.dr. J.J. Piek

05503: ICIN-NHS Cell therapy program
Translational studies Hebe
september 2006
Projectleider: Prof.dr. P.A.F.M. Doevendans

05504: Hebe 1 study folluw up
maart 2009
Projectleider: Prof.dr. A.C. van Rossum

05601: Prima study
Does serum galectin-3 measurement allow to predict worsening heart failure?
januari 2005 - januari 2013
Projectleider: Prof.dr. Y.M. Pinto

06001: Dual frequency probe study
Study of special ultrasound imaging modalities.
februari 2006
Projectleider: Prof.dr.ir N. de Jong

06003: Special ultrasound imaging modalities study
Instantaneous non-invasive ultrasonic measurement of bladder volume.
februari 2009
Projectleider: Prof.dr.ir N. de Jong

06004: Directing adipose derived stem cells with microbubbles
Directing adipose derived stem cells to the area at risk in the heart after myocardial infarction using targeted microbubbles.
januari 2009 - juni 2013
Projectleider: Prof.dr.ir N. de Jong

06101: Preventing Sudden Cardiac Death
A Leducq Foundation Trans-Atlantic Network of Excellence.
oktober 2005
Projectleider: Mw. Dr. C.R. Bezzina

06102: Towards genetic risk stratification
Towards genetic risk stratification for disease progression and outcome in heart failure.
januari 2009 - januari 2013
Projectleider: Mw. Dr. C.R. Bezzina

06302: Arrest 11
Drug-related sudden cardiac death.
oktober 2007
Projectleider: Dr. H.L. Tan

06303: Activated platelets
The role of activated platelets in the occurrence of ventricular fibrillation.
september 2008 - september 2012
Projectleider: Dr. H.L. Tan

06307: Arrest 11
januari 2009 - januari 2013
Projectleider: Dr. H.L. Tan

06402: Agnes study
Genome wide association study.
oktober 2008 - oktober 2012
Projectleider: Mw. Dr. C.R. Bezzina

06701: Longitudinale Fallot studie
Early diagnosis of right ventricular dysfunction in patients operated for tetralogy of Fallot.
mei 2007
Projectleider: Prof.dr. W.A. Helbing

06901: ARVD/C
Arrhythmogenic right ventricular dysplasia / cardiomyopathy
april 2008 - mei 2012
Projectleider: Prof. dr. R.N.W. Hauer

06903: ARVD/ C
Arrhythmogenic right ventricular dysplasia / cardiomyopathy
september 2011 - september 2012
Projectleider: Prof. dr. R.N.W. Hauer

07002: CTMM Triumph groep de Windt
Heart failure is a progressive disease with major impact on patients and society. The two major causes of heart failure are overload of the left ventricle as a result of deteriorating heart tissue, an
oktober 2008 - oktober 2013
Projectleider: Prof.dr. L.J. de Windt

07004: CTMM Triumph groep Pinto
oktober 2008 - oktober 2013
Projectleider: Prof.dr. Y.M. Pinto

07005: CTMM Cohfar
Biomarkers to predict cardiac failure, arrhythmias and success of treatment
januari 2010 - oktober 2013
Projectleider: Dhr. J.C.H. Weijers

07006: CTMM Circulating Cells groep Pasterkamp
oktober 2008 - december 2013
Projectleider: Prof.dr. G. Pasterkamp

07008: CTMM Triumph NHS Award 2011
augustus 2011 - augustus 2012
Projectleider: Prof.dr. D.J.G.M. Duncker

07101: BIOMArCS
Do biomarkers predict incident myocardial infarction?
juli 2007 - juni 2012
Projectleider: Prof.dr.ir. H. Boersma

07201: SYNOP2L
The role of SYNOP2L, a novel proteine expressed in cardiac and skeletal muscle, in sarcomere formation and stabilization
maart 2007
Projectleider: Mw. Prof.dr. C.L. Mummery

07302: Mouse genomics and zebrafish reverse genetics
Molecular regulation of vasculogenesis in development and ischemic disease
juli 2009 - juli 2014
Projectleider: Dr. H.J. Duckers

07401: NELU study
Identification of high risk plaques: screening for rupture-prone atherosclerotic plaques with molecular MRI
september 2007
Projectleider: Prof.dr. G. Pasterkamp

07501: Simon Stevin Meesterschap van der Steen
juni 2007 - augustus 2013
Projectleider: Prof.dr.ir. A.F.W. van der Steen

07601: Careful
The yield of cardio-genetic screening in first degree relatives of sudden cardiac death and unexplained death victims < 46 years
september 2007
Projectleider: Dr. A. Mosterd

07901: Comparison of plaque observations
A systematic comparison of plaque observations and their prognostic value between patients presenting with acute coronary syndromes and with stable coronary artery disease using non-invasive 64-slice
juni 2008 - juni 2012
Projectleider: Prof. dr. J.J. Bax

07902: Vulnerability assessment
Vulnerability assessment of atherosclerotic plaques with non-invasive multimodality imaging
januari 2010 - januari 2013
Projectleider: Prof. dr. J.J. Bax

08001: Plaque rupture in mice
Biomechanics of vulnerable plaque rupture
juni 2009 - juni 2012
Projectleider: Dr. F. Gijsen

08301: Prevention of atrial fibrillation
Markers for stretch and pacing induced structural remodeling and the preventive efficacy of upstream therapy
februari 2008 - december 2012
Projectleider: Mw. Prof.dr. I.C. van Gelder

08401: Micro RNA function in heart failure
groep Pinto
juni 2008 - juni 2013
Projectleider: Prof.dr. Y.M. Pinto

08402: Micro RNA function in heart failure
groep de Windt
juni 2008 - juni 2013
Projectleider: Prof.dr. L.J. de Windt

08501: Transtalantic Fellowship Leducq
Role of inflammation, renal function and NOS1AP gene in ventricular arrhythmia and sudden cardiac death
augustus 2008
Projectleider: Prof.dr. A.A.M. Wilde

08701: Repopulating the heart
Strategies to enhance the capacity of cardiac stem cells.
april 2009 - december 2013
Projectleider: Dr. S.A.J. Chamuleau

08901: Pulmonale Hypertensie
april 2010 - juni 2012
Projectleider: Dr. A.P.J. van Dijk

09001: SNP Analyses
juni 2010 - oktober 2012
Projectleider: Prof.dr. G. Pasterkamp

09201: Inverse project
Non-invasive electrocardiographic imaging to assess cardiac electrophysiological integrity
juli 2010 - juli 2014
Projectleider: Prof.dr.ir. J.M.T. de Bakker

09601: Right Ventricular adaption
Right Ventricular adaptation to increased afterload
augustus 2010 - augustus 2014
Projectleider: Dr. G.T.J. Sieswerda

10001: Early atherosclerosis study
Vascular (dys)function during developing and established atherosclerosis.
januari 2011
Projectleider: Prof.dr. D.J.G.M. Duncker

10201: Zahara III study
The clinical and molecular relation between maternal congenital heart defects and premature labour and birth.
mei 2011 - mei 2015
Projectleider: Dr. C. Ris-Stalpers

10701: ESC fellowship Julien Barc
augustus 2011 - augustus 2012
Projectleider: Mw. Dr. C.R. Bezzina

10901: MRI Hypertrofische Cardiomyopathie
november 2011 - juni 2015
Projectleider: Prof.dr. A.C. van Rossum

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